The severe acute respiratory syndrome (SARS) epidemic started in late Fine/Thin shampoo 2002 and swiftly spread across 5 continents with a mortality rate of around 10%.Although the epidemic was eventually controlled through the implementation of strict quarantine measures, there continues a need to investigate the SARS coronavirus (SARS-CoV) and develop interventions should it re-emerge.Numerous studies have shown that neutralizing antibodies against the virus can be found in patients infected with SARS-CoV within days upon the onset of illness and lasting up to several months.In contrast, there is little data on the kinetics of T cell responses during SARS-CoV infection and little is known about their role in the recovery process.However, recent studies in mice suggest the importance of T cells in viral clearance during SARS-CoV infection.
Moreover, a growing number of studies have investigated the memory T cell responses in recovered SARS patients.This review covers the available literature on the emerging importance of T cell responses in SARS-CoV infection, particularly on the mapping of cytotoxic T lymphocyte (CTL) Household Cleaning, Skincare, Hygiene, Food and Medical Products epitopes, longevity, polyfunctionality and human leukocyte antigen (HLA) association as well as their potential implications on treatment and vaccine development.Emerging Microbes & Infections (2012) 1, e23; doi:10.1038/emi.2012.
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